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Energy-saving 1

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clinical decision support systems 1

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Structural effect of fluorophore on phenylboronic acid fluorophore/cyclodextrin complex for selective glucose recognition

Takeshi Hashimoto, Mio Kumai, Mariko Maeda, Koji Miyoshi, Yuji Tsuchido, Shoji Fujiwara, Takashi Hayashita

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 1,   Pages 53-60 doi: 10.1007/s11705-019-1851-y

Abstract: Based on the design of the fluorescent site of a fluorescent probe, we have created a unique system that changes its twisting response to sugar. Two probes were synthesized, in which phenylboronic acid and two kinds of aromatic fluorescent site (pyrene or anthracene) were conjugated by an amide bond. In the fluorescence measurement of pyrene-type probe , dimer fluorescence was observed at high pH. In induced circular dichroism (ICD) experiments, a response was observed only in the presence of glucose and -cyclodextrin, and no response was seen with fructose. On the other hand, in the fluorescence measurement of anthracene-type probe , dimer fluorescence was observed in the presence of both glucose and galactose, and the fluorescence was different from the case of fructose. When the ICD spectra of these inclusion complexes were measured, an inversion of the Cotton effect, which indicates a change in the twisted structure, was observed in galactose and glucose. These differences in response to monosaccharides may originate in the interaction between the fluorescent site and the cyclodextrin cavity.

Keywords： sugar recognition     phenylboronic acid     cyclodextrin     fluorescence response     induced circular dichroism    

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Current applications of artificial intelligence for intraoperative decision support in surgery

Hashimoto

Frontiers of Medicine 2020, Volume 14, Issue 4,   Pages 369-381 doi: 10.1007/s11684-020-0784-7

Abstract: Research into medical artificial intelligence (AI) has made significant advances in recent years, including surgical applications. This scoping review investigated AI-based decision support systems targeted at the intraoperative phase of surgery and found a wide range of technological approaches applied across several surgical specialties. Within the twenty-one ( =21) included papers, three main categories of motivations were identified for developing such technologies: (1) augmenting the information available to surgeons, (2) accelerating intraoperative pathology, and (3) recommending surgical steps. While many of the proposals hold promise for improving patient outcomes, important methodological shortcomings were observed in most of the reviewed papers that made it difficult to assess the clinical significance of the reported performance statistics. Despite limitations, the current state of this field suggests that a number of opportunities exist for future researchers and clinicians to work on AI for surgical decision support with exciting implications for improving surgical care.

Keywords： artificial intelligence     decision support     clinical decision support systems     intraoperative     deep learning     computer vision     machine learning     surgery    

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Energy reduction of a submerged membrane bioreactor using a polytetrafluoroethylene (PTFE) hollow-fiber membrane

Miyoshi, Thanh Phong Nguyen, Terumi Tsumuraya, Hiromu Tanaka, Toru Morita, Hiroki Itokawa, Toshikazu Hashimoto

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 3, doi: 10.1007/s11783-018-1018-y

Abstract: In this study, we modified a polytetrafluoroethylene (PTFE) hollow-fiber membrane element used for submerged membrane bioreactors (MBRs) to reduce the energy consumption during MBR processes. The high mechanical strength of the PTFE membrane made it possible to increase the effective length of the membrane fiber from 2 to 3 m. In addition, the packing density was increased by 20% by optimizing the membrane element configuration. These modifications improve the efficiency of membrane cleaning associated with aeration. The target of specific energy consumption was less than 0.4 kWh·m in this study. The continuous operation of a pilot MBR treating real municipal wastewater revealed that the MBR utilizing the modified membrane element can be stably operated under a specific air demand per membrane surface area (SAD ) of 0.13 m ·m ·hr when the daily-averaged membrane fluxes for the constant flow rate and flow rate fluctuating modes of operation were set to 0.6 and 0.5 m ·m ·d , respectively. The specific energy consumption under these operating conditions was estimated to be less than 0.37 kWh·m . These results strongly suggest that operating an MBR equipped with the modified membrane element with a specific energy consumption of less than 0.4 kWh·m is highly possible.

Keywords： Energy-saving     Membrane bioreactor     Polytetrafluoroethylene (PTFE) membrane     Hollow fiber     Power consumption    

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Intratumoral Bacteria Dysbiosis Is Associated with Human Papillary Thyroid Cancer and Correlated with Oncogenic Signaling Pathways Article

Shuang Yu, Yanqiang Ding, Xuejie Wang, Siu Kin Ng, Siting Cao, Weixin Liu, Zhuming Guo, Yubin Xie, Shubin Hong, Lixia Xu, Xiaoxing Li, Jie Li, Weiming Lv, Sui Peng, Yanbing Li, Joseph J.Y. Sung, Jun Yu, Haipeng Xiao

Engineering 2023, Volume 28, Issue 9,   Pages 179-192 doi: 10.1016/j.eng.2023.01.007

Abstract: >Erwinia, Bacillus, and Acinetobacter) were found to be enriched in PTC with Hashimoto

Keywords： Papillary thyroid cancer     Benign thyroid nodule     Bacteria     Transcriptome     Hashimoto's thyroiditis    

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Title Author Date Type Operation

Structural effect of fluorophore on phenylboronic acid fluorophore/cyclodextrin complex for selective glucose recognition

Takeshi Hashimoto, Mio Kumai, Mariko Maeda, Koji Miyoshi, Yuji Tsuchido, Shoji Fujiwara, Takashi Hayashita

Journal Article

Current applications of artificial intelligence for intraoperative decision support in surgery

Hashimoto

Journal Article

Energy reduction of a submerged membrane bioreactor using a polytetrafluoroethylene (PTFE) hollow-fiber membrane

Miyoshi, Thanh Phong Nguyen, Terumi Tsumuraya, Hiromu Tanaka, Toru Morita, Hiroki Itokawa, Toshikazu Hashimoto

Journal Article

Intratumoral Bacteria Dysbiosis Is Associated with Human Papillary Thyroid Cancer and Correlated with Oncogenic Signaling Pathways

Shuang Yu, Yanqiang Ding, Xuejie Wang, Siu Kin Ng, Siting Cao, Weixin Liu, Zhuming Guo, Yubin Xie, Shubin Hong, Lixia Xu, Xiaoxing Li, Jie Li, Weiming Lv, Sui Peng, Yanbing Li, Joseph J.Y. Sung, Jun Yu, Haipeng Xiao

Journal Article